8- Laboratory Challenges of Female Infertility Diagnosis - Part 8 (Hormone Anti-Molerin Hormone or AMH)

8- Laboratory Challenges of Female Infertility Diagnosis - Part 8 (Hormone Anti-Molerin Hormone or AMH)


Tips on the hormone antimullerin

What is the anti-mulerin (AMH) hormone? .

Molerin inhibitory hormone is produced in the testicular tissue of men and the ovaries of women, and its amount varies according to age and sex.

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What is the importance of molarin inhibitory hormone in humans? .

This hormone is produced early in the development of the male fetus by the testicular tissue and promotes the growth of male sexual organs, while preventing the growth of female sexual organs. .

AMH is high in male infants and stays high until they are 2 years old, then gradually decreases and reaches its minimum at puberty.

AMH is not produced in a girl's fetus, and the absence of this hormone allows a woman's genitals to grow. The level of this hormone in girls is low until puberty. In the pre-pubertal period, its production in the ovaries begins and its level increases.

AMH levels gradually decrease over the years and will be almost immeasurable during premenopausal and menopausal periods.

Importance of ovarian reserve testing Women with reduced ovarian reserve have low fertility and are at higher risk for miscarriage.

Measurement of this hormone can help estimate egg storage and the likelihood of pregnancy.


AMH reduction cases:

1- Aging, severe and sudden decline in menopausal age as the fastest marker of monopoly diagnosis (faster than FSH)

2 - Obesity (obese women have a 65% reduction in AMH compared to thin people)

3- Chemotherapy (after ovarian chemotherapy, measuring AMH can assess the damage to the ovaries and the number of eggs)

AMH increase cases:

1- The most important thing to increase AMH levels is the presence of PCOS polycystic ovary disease

2. The next case is ovarian cancer (Granulosa cell tumor), which can produce many eggs but with defective function. In these people, reducing AMH after treatment is an effective sign of treatment.

Therefore, accurate measurement of this hormone is essential before starting treatment.

Can low AMH levels be treated?

In general, we expect the AMH level to decrease with age, but it has been observed with proper nutrition (increased consumption of fruits and vegetables, complex carbohydrates such as brown rice, organic foods, a variety of seafood, fiber). And ...), taking supplements (especially vitamin D3, coenzyme Q10, inositol, L-arginine), increasing physical activity, reducing stress and smoking cessation can make eggs and ovaries healthier and thus increase AMH observed.


Who should have an egg storage test? .

- Women under the age of 38 who intend to delay their pregnancy due to malignancy (under chemotherapy or radiotherapy) or benign ones such as personal or social issues.

If such people are found to have low ovarian reserve as a result of this test, they should become pregnant sooner to increase their chances of having a baby.

- Women over the age of 42 are not good candidates for this test because they naturally (due to old age) have less ovarian reserve. .

- Another group that is a candidate for this test are women who are at high risk for reduced ovarian reserve, including people with a family history of ovarian failure or people with autoimmune diseases, and finally people. Who have undergone chemotherapy or have a history of ovarian surgery.

Are ovarian reserve tests reliable for life expectancy planning?

The stages of fertility are controlled by a number of factors, including individual, genetic, racial, environmental, and lifestyle factors.

Changes in one or more of these characteristics disrupt the counseling of childbearing for women who intend to delay their childbearing for an indefinite period of time during childbirth, thereby increasing their risk of natural infertility. Won.

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What are the criteria for measuring ovarian response to ovulation-stimulating gonadotropins and identifying the right people for IVF?

In general, the number of antral follicles visible on ultrasound and high AMH levels is a sign of fertility potential.

Low AMH levels are a sign that both the number and quality of eggs are poor.

1- The number of antral follicles, if it is less than or equal to 4, is the answer to poor responder and if it is more than 16, the answer to high response is high responder. .

2- If the AMH level is less than 0.75 ng / ml, the response to treatment is poor, and if it is more than 3.5 ng / ml, the response to treatment is severe.

3- If the FSH level is higher than IU / L 8.9, the response to treatment is weak and if it is less than IU / L 4.0, the response to treatment is severe.

RelatedNews 8- Laboratory Challenges of Female Infertility Diagnosis - Part 8 (Hormone Anti-Molerin Hormone or AMH)

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