The effect of father's age on increasing the risk of Down syndrome

The effect of father's age on increasing the risk of Down syndrome

Research has shown that fathers over the age of 40 who marry mothers over the age of 35 are twice as likely to have Down Syndrome as children under the age of 24 who have been married to mothers over the age of 35. The only variable in this study is the father's age).

Also, in women 40 years of age and older, the risk of Down Syndrome in children increases by 50% as the father gets older.
Therefore, the biggest cause of Down syndrome is increasing age in both parents.

A 15-year study in the United States found that the number of mothers and fathers over the age of 35 increased by 111% and 60%, respectively, indicating an increase in the prevalence of Down syndrome in the coming years.

The prevalence of Down syndrome in parents over the age of 40 is 1: 165, which is approximately 4 to 5 times higher than its prevalence in the normal population.